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Do not stop Donepezil hydrochloride or change the dose yourself. Swedish 6 Month Study (10 mg/day) The effectiveness of order Aricept as a treatment for order severe Alzheimers disease is demonstrated by the results of a randomized, double-blind, placebo-controlled clinical study conducted in Sweden (6 month study) in patients order with probable or possible. 12.3 Pharmacokinetics Pharmacokinetics of donepezil are linear over a dose range of 1-10 mg order given once daily. Keep Aricept and aricept all medicines out of the reach of children. The maximum recommended dosage of Aricept in patients with moderate to severe Alzheimers disease is 23 mg per day. These patients were titrated to a dose of 10 mg/day over a 6-week period. Donepezil hydrochloride is postulated to exert its aricept therapeutic effect by enhancing cholinergic function. In vitro studies have shown that the cytochrome order P450 isoenzymes 3A4 and to a minor extent 2D6 are involved in the metabolism of donepezil. Results aricept of a controlled clinical trial in moderate to severe Alzheimers Disease that compared aricept 23 mg once daily to 10 mg once daily suggest that a 23 mg dose of aricept provided additional benefit. Drugs Highly Bound to Plasma Proteins Drug displacement studies have been performed in vitro between this highly bound drug (96) and other drugs such as furosemide, digoxin, and warfarin. Inducers of CYP 3A (e.g., phenytoin, carbamazepine, dexamethasone, order rifampin, and phenobarbital) could increase the rate of elimination of Donepezil hydrochloride. Gender and Race No specific pharmacokinetic study was conducted to investigate the effects of gender and race on the disposition of Donepezil hydrochloride. The percent of patients who discontinued treatment due to vomiting in the 23 mg group was markedly higher than in the 10 mg group (2.9. 8 USE IN specific populations.1 Pregnancy Pregnancy Category C There are no adequate or well-controlled studies in pregnant women. 4.9 Overdose The estimated median lethal dose of donepezil hydrochloride following administration of a single oral dose in mice aricept and rats is 45 and 32 mg/kg, respectively, or approximately 225 and 160 times the maximum recommended human dose of 10 mg per day. Drugs Highly Bound To Plasma Proteins Drug displacement studies have been performed in vitro between this highly bound drug (96) and other drugs such as furosemide, digoxin, and warfarin. For more information, ask the doctor or pharmacist. Drug interaction studies performed in vitro show that ketoconazole and quinidine, inhibitors of CYP3A4 and 2D6 respectively, inhibit donepezil metabolism. The effect size for the 10 mg/day group may aricept appear to be slightly larger than that for 5 mg/day. The most common adverse reactions leading to discontinuation, defined as those occurring in at least 2 of Aricept patients and at twice or more the incidence seen in placebo, were anorexia (2. The Percentages of Randomized Patients Within Each Treatment Group Who Completed the Study Were: Placebo 93, 5 mg/day 90, and 10 mg/day. Table 4 lists adverse reactions that occurred in at least 2 of patients in pooled placebo-controlled trials who received Aricept 5 mg or 10 mg and for which the rate of occurrence was greater order for patients treated with Aricept than with placebo. If Aricept is missed for 7 days or more, talk with the doctor before starting again. Consult your doctor before breast -feeding. The adas-cog scoring range is from 0 to 70, with higher scores indicating greater cognitive impairment. The range of patient exposure was from 1 to over 500 aricept days. Who should not take Aricept? Effect Of Other Drugs On The Metabolism Of aricept Ketoconazole and quinidine, strong inhibitors of CYP450 3A and 2D6, respectively, inhibit donepezil metabolism in vitro. Approximately 63 of patients were women, and 37 were men. Tell the doctor about all the patient's present or past health problems. You can ask your pharmacist or doctor for information about Aricept that is written for health professionals. Legal Category, pOM: Prescription only medicine. Figure 12 illustrates the cumulative percentages of patients from each of the two treatment groups who attained the measure of improvement order in SIB score shown on the X-axis. This leaflet summarizes the most important information about Donepezil hydrochloride.

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